Product :
GNE-6776
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Chemical Information
| Product name：GNE-6776 |
Purity：98% min |
| CAS NO：2009273-71-4 |
Solubility：DMSO : ≥ 310 mg/mL (889.78 mM) |
| Molecular Formula：C20H20N4O2 |
Package：Package according to customer requirements |
| Molecular Weight：348.40 |
Storage：Store at -20℃ |
Remarks
GNE-6776 non-covalently targets USP7 12 Å distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100 μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases.