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GNE-6776

GNE-6776 2009273-71-4
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Chemical Information
Product name:GNE-6776 Purity:98% min
CAS NO:2009273-71-4 Solubility:DMSO : ≥ 310 mg/mL (889.78 mM)
Molecular Formula:C20H20N4O2 Package:Package according to customer requirements
Molecular Weight:348.40 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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Remarks
GNE-6776 non-covalently targets USP7 12 Å distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100 μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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