MN58b

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Chemical Information

Product name：MN58b	Purity：98% min
CAS NO：203192-01-2	Solubility：DMSO : 14.71 mg/mL (22.97 mM)
Molecular Formula：C₃₂H₄₀Br₂N₄	Package：Package according to customer requirements
Molecular Weight：640.495	Storage：-20 ℃

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Remarks

MN58b is a selective inhibitor of choline kinase α (CHKα) and inhibits phosphocholine synthesis. MN58b induces apoptosis to reduce cell growth. MN58b also has antitumoral activity.

References

[1]. Mazarico JM, et al. Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. Mol Cancer Ther. 2016 Feb;15(2):323-33.

[2]. Al-Saffar NM, et al. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res. 2006 Jan 1;66(1):427-34.