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XMU-MP-1

XMU-MP-1 2061980-01-4
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Chemical Information
Product name:XMU-MP-1 Purity:98% min
CAS NO:2061980-01-4 Solubility:DMSO : ≥ 30 mg/mL (72.03 mM)
Molecular Formula:C17H16N6O3S2 Package:Package according to customer requirements
Molecular Weight:416.474 Storage:Store at -20℃
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Remarks

XMU-MP-1 is a potent and selective MST1/2 inhibitor with IC50 values of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively.. XMU-MP-1 blocked MST1/2 kinase activities, thereby activating the downstream effector Yes-associated protein and promoting cell growth. XMU-MP-1 displayed excellent in vivo pharmacokinetics and was able to augment mouse intestinal repair, as well as liver repair and regeneration, in both acute and chronic liver injury mouse models at a dose of 1 to 3 mg/kg via intraperitoneal injection.


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