Product :
NSC55712 TPT-260 2HCl
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Chemical Information
| Product name：NSC55712 TPT-260 2HCl |
Purity：98% min |
| CAS NO：2076-91-7 |
Solubility：DMSO : 100 mg/mL (300.01 mM) |
| Molecular Formula：C8H13ClN4S3 |
Package：Package according to customer requirements |
| Molecular Weight：296.864 |
Storage：Store at -20℃ |
Remarks
TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. **** Please also see similar products: TPT-197; TPT-260; TPT-172.
References
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.