ZM 336372

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Chemical Information

Product name：ZM 336372	Purity：98% min
CAS NO：208260-29-1	Solubility：DMSO : 50 mg/mL (128.39 mM)
Molecular Formula：C₂₃H₂₃N₃O₃	Package：Package according to customer requirements
Molecular Weight：389.447	Storage：Store at -20℃

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Remarks

ZM336372 is a Raf-1 activating agent, has been shown to cause growth inhibition and suppression of hormone secretion in a neuroendocrine cell line. ZM336372 causes growth inhibition, suppression of hormone secretion, and up-regulation of cell cycle inhibitors in a human hepatocellular carcinoma cell line, similar to that previously seen in NETs.

Raf Inhibitors Related Products:

Vemurafenib; PLX-4720; Debrafenib; Regorafenib; GDC-0879; RAF265 (CHIR-265); AZ-628; SB590885; TAK-632; B-Raf IN 1; AZ304; Dabrafenib Mesylate; RAF709; LY3009120; RO5126766; Doramapimod; MLN2480 ; GW5074

References

[1]. Hall-Jackson CA, et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol, 1999, 6(8), 559-568.

[2]. Wartenberg M, et al. Reactive oxygen species-mediated regulation of eNOS and iNOS expression in multicellular prostate tumor spheroids. Int J Cancer, 2003, 104(3), 274-282.