YM-087 Conivaptan

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Chemical Information

Product name：YM-087 Conivaptan	Purity：98% min
CAS NO：210101-16-9	Solubility：Soluble in DMSO
Molecular Formula：C₃₂H₂₆N₄O₂	Package：Package according to customer requirements
Molecular Weight：498.586	Storage：Store at -20℃

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Remarks

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist). Conivaptan inhibits two of the three subtypes of the vasopressin receptor (V1a and V2). Effectively, it causes iatrogenic nephrogenic diabetes insipidus.

Properties:
Density: 1.298g/cm3
Boiling Point: 751.2ºC at 760 mmHg
Flash Point: 408.1ºC
Refractive Index: 1.698
Vapor Pressure: 1.89E-22mmHg at 25°C

References

1: Decker D, Collier L, Lau T, Olivera R, Roma G, Leonardo C, Seifert H, Rowe D, Pennypacker KR. The Effects of Clinically Relevant Hypertonic Saline and Conivaptan Administration on Ischemic Stroke. Acta Neurochir Suppl. 2016;121:243-50. doi: 10.1007/978-3-319-18497-5_43. PubMed PMID: 26463956.

2: Zeynalov E, Jones SM, Seo JW, Snell LD, Elliott JP. Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice. PLoS One. 2015 Aug 14;10(8):e0136121. doi: 10.1371/journal.pone.0136121. eCollection 2015. PubMed PMID: 26275173; PubMed Central PMCID: PMC4537303.