PF-06700841 P-Tosylate

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Chemical Information

Product name：PF-06700841 P-Tosylate	Purity：98% min
CAS NO：2140301-96-6	Solubility：DMSO : 62.5 mg/mL (111.29 mM)
Molecular Formula：C₂₅H₂₉F₂N₇O₄S	Package：Package according to customer requirements
Molecular Weight：561.6088	Storage：4°C, stored under nitrogen

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Remarks

PF-06700841 P-Tosylate is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 with IC50 of 17 nM and 23 nM, respectively. PF-06700841 P-Tosylate also inhibits JAK2 and JAK3 with IC50 of 77 nM and 6.49 μM, respectively.

References

[1]. Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.