Selpercatinib LOXO-292

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Chemical Information

Product name：Selpercatinib LOXO-292	Purity：98.0% min
CAS NO：2152628-33-4	Solubility：DMSO : 62.5 mg/mL (118.91 mM)
Molecular Formula：C₂₉H₃₁N₇O₃	Package：Package according to customer requirements
Molecular Weight：525.602	Storage：Store at -20℃

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Remarks

Selpercatinib, also known as LOXO-292, is a potent and selective RET inhibitor with antineoplastic properties. LOXO-292 selectively binds to and targets various RET mutants and RET-containing fusion products. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. Selpercatinib was approved in May 2020.

References

[1]. Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

[2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018.