Product :
HS-1371
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Chemical Information
| Product name：HS-1371 |
Purity：98% min |
| CAS NO：2158197-70-5 |
Solubility：DMSO : 15 mg/mL (39.01 mM) |
| Molecular Formula：C24H24N4O |
Package：Package according to customer requirements |
| Molecular Weight：384.474 |
Storage：Store at -20℃ |
Remarks
HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.