Decitabine

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Chemical Information

Product name：Decitabine	Purity：98% min
CAS NO：2353-33-5	Solubility：DMSO : ≥ 50 mg/mL (219.10 mM)
Molecular Formula：C₈H₁₂N₄O₄	Package：Package according to customer requirements
Molecular Weight：228.205	Storage：Store at -20℃

Quality control

COA

Remarks

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.

References

[1]. Nakamura M, et al. Decitabine inhibits tumor cell proliferation and up-regulates E-cadherin expression in Epstein-Barr virus-associated gastric cancer. J Med Virol. 2016 Jul 19.

[2]. Zhang C, et al. Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines. Clin Proteomics. 2016 Jul 5;13:14.