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Product :

STM2457

STM2457 2499663-01-1
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Chemical Information
Product name:STM2457 Purity:98.0% min
CAS NO:2499663-01-1 Solubility:DMSO : 270 mg/mL (607.38 mM; Need ultrasonic)
Molecular Formula:C25H28N6O2 Package:Package according to customer requirements
Molecular Weight:444.539 Storage:Store at -20℃
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Remarks

STM2457 is a highly potent and selective first-in-class catalytic inhibitor of METTL3. Treatment of tumours with STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis. These cellular effects are accompanied by selective reduction of m6A levels on known leukaemogenic mRNAs and a decrease in their expression consistent with a translational defect. Pharmacological inhibition of METTL3 in vivo leads to impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML.

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