CP-547632

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Chemical Information

Product name：CP-547632	Purity：99% min
CAS NO：252003-65-9	Solubility：DMSO : ≥ 115 mg/mL (216.00 mM)
Molecular Formula：C₂₀H₂₄BrF₂N₅O₃S	Package：Package according to customer requirements
Molecular Weight：CC20H24BrF2N5O3S	Storage：Store at -20℃

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Remarks

CP-547632, also known as PAN-90806, is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies.

Properties:
Density: 1.532
Boiling Point: 548.601ºC at 760 mmHg

References

[1]. Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63(21):7301-9.