L-778123 hydrochloride

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Chemical Information

Product name：L-778123 hydrochloride	Purity：98% min
CAS NO：253863-00-2	Solubility：DMSO : ≥ 25 mg/mL (56.52 mM)
Molecular Formula：C₂₂H₂₁Cl₂N₅O	Package：Package according to customer requirements
Molecular Weight：442.341	Storage：Store at -20℃

Quality control

Remarks

L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.

Properties:
Boiling Point: 698.9ºC at 760 mmHg
Flash Point: 376.5ºC
Vapor Pressure: 2.22E-19mmHg at 25°C

References

[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758.

[2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.