Felbamate is an anti-epileptic drug used in the treatment of epilepsy. Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptors, the relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
Properties:
Appearance & Physical State: white crystalline powder
Density: 1.275 g/cm3
Boiling Point: 511.9ºC at 760 mmHg
Melting Point: 148-150ºC
Flash Point: 288.4ºC
Refractive Index: 1.558
Vapor Pressure: 1.36E-10mmHg at 25°C