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PD173955

PD173955 260415-63-2
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Chemical Information
Product name:PD173955 Purity:98% min
CAS NO:260415-63-2 Solubility:DMSO: ≥ 32 mg/mL
Molecular Formula:C21H16Cl2N4OS Package:Package according to customer requirements
Molecular Weight:443.349 Storage:Store at -20℃
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Remarks
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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