AICAR Acadesine

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Chemical Information

Product name：AICAR Acadesine	Purity：98% min
CAS NO：2627-69-2	Solubility：DMSO : ≥ 30 mg/mL (116.18 mM)
Molecular Formula：C₉H₁₄N₄O₅	Package：Package according to customer requirements
Molecular Weight：258.231	Storage：Store at -20℃

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Remarks

Acadesine, also known as AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

Properties:

Appearance & Physical State: Solid
Density: 2.06 g/cm3
Melting Point: 214-215ºC
Boiling Point: 726.3ºC at 760 mmHg
Flash Point: 393.1ºC
Refractive Index: 1.821
Storage Condition: -20ºC
Vapor Pressure: 3.83E-22mmHg at 25°C

References

[1]. Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54

[2]. Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.