Telomestatin

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Chemical Information

Product name：Telomestatin	Purity：98% min
CAS NO：265114-54-3	Solubility：Soluble in DMSO
Molecular Formula：C₂₆H₁₄N₈O₇S	Package：Package according to customer requirements
Molecular Weight：582.504	Storage：Store at -20℃

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Remarks

Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

References

1: Abraham Punnoose J, Ma Y, Li Y, Sakuma M, Mandal S, Nagasawa K, Mao H. Adaptive and Specific Recognition of Telomeric G-quadruplexes via Polyvalency Induced Unstacking of Binding Units. J Am Chem Soc. 2017 May 15. doi: 10.1021/jacs.7b00607. [Epub ahead of print] PubMed PMID: 28505453.

2: Maleki P, Ma Y, Iida K, Nagasawa K, Balci H. A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions. Nucleic Acids Res. 2017 Jan 9;45(1):288-295. doi: 10.1093/nar/gkw1090. Epub 2016 Nov 29. PubMed PMID: 27899628; PubMed Central PMCID: PMC5224478.