Etravirine

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Chemical Information

Product name：Etravirine	Purity：99% min
CAS NO：269055-15-4	Solubility：DMSO : 50 mg/mL (114.87 mM)
Molecular Formula：C₂₀H₁₅BrN₆O	Package：Package according to customer requirements.
Molecular Weight：435.285	Storage：Store at -20℃

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COA

Remarks

Etravirine, also known as TMC 125 and R 165335, is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It was also approved in 2008. Etravirine, in combination with other anti-retrovirals, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients, who have evidence of viral replication and HIV-1 strains resistant to a non-nucleoside reverse transcriptase inhibitor (NNRTI) and other antiretroviral agents.

Reverse Transcriptase Inhibitors Related Prodcuts:

Didanosine; Dapivirine; Tenofovir; Emtricitabine; Entecavir; Entecavir hydrate; Adefovir; Adefovir dipivoxil; Nevirapine; Lamivudine; Stavudine; Telbivudine; Zidovudine; Zalcitabine ; Alovudine

References

[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468

[2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.