Gambogic Acid

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Chemical Information

Product name：Gambogic Acid	Purity：98% min
CAS NO：2752-65-0	Solubility：DMSO : ≥ 100 mg/mL (159.05 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₃₈H₄₄O₈	Package：Package according to customer requirements
Molecular Weight：628.751	Storage：Store at -20℃

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Remarks

Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials. Gambogic acid inhibits cell proliferation, angiogenesis and metastasis. Gambogic acid is currently in clinical trials in China.

References

[1]. Zhai D, et al. Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2008 Jun;7(6):1639-46.

[2]. Wang LH, et al. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. Br J Cancer. 2014 Jan 21;110(2):341-52.