NPS-2143

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Chemical Information

Product name：NPS-2143	Purity：98% min
CAS NO：284035-33-2	Solubility：10 mM in DMSO
Molecular Formula：C₂₄H₂₅ClN₂O₂	Package：Package according to customer requirements
Molecular Weight：408.921	Storage：Store at -20℃

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Remarks

NPS-2143 is a novel potent and selective antagonist of Ca2+ receptor with IC50 of 43 nM.

Properties:
Density: 1.23 g/cm3
Boiling Point: 608.4ºC at 760 mmHg
Refractive Index: 1.631
Vapor Pressure: 1.17E-15mmHg at 25°C

References

[1]. Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

[2]. Rybczynska A, et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95.