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Remarks
BML-190, also known as IMMA and LM-4131 or Indomethacin Morpholinylamide, is selective CB2 receptor agonist. The binding constant for the CB2 receptor is 435 nM compared to >20,000 nM for the cannabinoid receptor, CB1. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB(2) receptor and 16z44. BML-190 acts as inverse agonist at the human CB(2) receptor acting via G alpha(i/o) and G alpha(q) family-coupled pathways.