SB408124

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Chemical Information

Product name：SB408124	Purity：98% min
CAS NO：288150-92-5	Solubility：DMSO : 50 mg/mL (140.30 mM);H2O : < 0.1 mg/mL
Molecular Formula：C₁₉H₁₈F₂N₄O	Package：Package according to customer requirements
Molecular Weight：356.369	Storage：Store at -20℃

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Remarks

SB-408124 is a elective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states.

References

[1]. Morairty SR, et al. Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.PLoS One. 2012;7(7):e39131. Epub 2012 Jul 2.

[2]. Melis MR, et al. Neuroendocrine regulatory peptide-1 and neuroendocrine regulatory peptide-2 influence differentially feeding and penile erection in male rats: sites of action in the brain.Regul Pept. 2012 Aug 20;177(1-3):46-52. Epub 2012 May 2.