SPP-301 Avosentan

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Chemical Information

Product name：SPP-301 Avosentan	Purity：98% min
CAS NO：290815-26-8	Solubility：DMSO : 6.67 mg/mL (13.91 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₂₃H₂₁N₅O₅S	Package：Package according to customer requirements
Molecular Weight：479.508	Storage：Store at -20℃

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Remarks

Avosentan, also known as SPP301, R-639, and RO 67-0565, is an endothelin receptor antagonist. Avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. Avosentan reduces albuminuria when added to standard treatment in people with type 2 diabetes and overt nephropathy but induces significant fluid overload and congestive heart failure.

References

[1]. Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA. Antidiuretic effects of the endothelin receptor antagonist avosentan. Front Physiol. 2012;3:103.

[2]. Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J. Effect of avosentan (SPP-301) in porcine ciliary arteries. Curr Eye Res. 2011 Feb;36(2):118-24.