P7C3

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Chemical Information

Product name：P7C3	Purity：99.0% min
CAS NO：301353-96-8	Solubility：DMSO : ≥ 33 mg/mL (69.59 mM)
Molecular Formula：C₂₁H₁₈Br₂N₂O	Package：Package according to customer requirements
Molecular Weight：474.19	Storage：Store at -20℃

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Remarks

P7C3 is a proneurogenic, neuroprotective agent. P7C3 protects newborn neurons from apoptotic cell death, and promotes neurogenesis in mice and rats in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals. P7C3 is orally available, nontoxic, stable in mice, rats, and cell culture, and capable of penetrating the blood-brain barrier.

References

[1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

[2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34.