MLN-4760

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Chemical Information

Product name：MLN-4760	Purity：98% min
CAS NO：305335-31-3	Solubility：DMSO : 100 mg/mL (233.48 mM; Need ultrasonic)
Molecular Formula：C₁₉H₂₃Cl₂N₃O₄	Package：Package according to customer requirements
Molecular Weight：428.31	Storage：Store at -20℃

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Remarks

MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

References

[1]. Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

[2]. Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33.