AHR-619 doxapram

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Chemical Information

Product name：AHR-619 doxapram	Purity：98% min
CAS NO：309-29-5	Solubility：Soluble in DMSO
Molecular Formula：C₂₄H₃₀N₂O₂	Package：Package according to customer requirements
Molecular Weight：378.507	Storage：Store at -20℃

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Remarks

Doxapram is a respiratory stimulant. Administered intravenously, Doxapram stimulates an increase in tidal volume and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. Doxapram induced changes in the electrophysiological properties of pre-inspiratory and inspiratory neurones. Results suggest that respiratory activity enhancement was likely to be induced via effects on the potassium channels of pre-inspiratory and inspiratory neurones and indicate the central actions of doxapram

Properties:

Density: 1.104 g/cm3
Boiling Point: 536.4ºC at 760 mmHg
Flash Point: 278.2ºC
Refractive Index: 1.562

References

[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785.

[2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.