CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 µM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9.
Chemical Name:
4-[3'-(2''-chlorophenyl)-2'-propen-1'-ylidene]-1-phenyl-3,5-pyrazolidinedione
Chemical Properties:
density: 1.405±0.06 g/cm3(Predicted)
pka: 8.26±0.20(Predicted)
DOCK Inhibitors Related Products:
TBOPP