ICA-121431

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Chemical Information

Product name：ICA-121431	Purity：98% min
CAS NO：313254-51-2	Solubility：DMSO : ≥ 44 mg/mL (97.88 mM)
Molecular Formula：C₂₃H₁₉N₃O₃S₂	Package：Package according to customer requirements
Molecular Weight：449.545	Storage：Store at -20℃

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Remarks

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy.

References

[1]. McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.