Product :
FLI-06
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Chemical Information
| Product name：FLI-06 |
Purity：98% min |
| CAS NO：313967-18-9 |
Solubility：DMSO : ≥ 38 mg/mL (86.66 mM) |
| Molecular Formula：C25H30N2O5 |
Package：Package according to customer requirements |
| Molecular Weight：438.516 |
Storage：Store at -20℃ |
Remarks
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer.