BPTES

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Chemical Information

Product name：BPTES	Purity：99.8% min
CAS NO：314045-39-1	Solubility：DMSO : 50 mg/mL (95.30 mM)
Molecular Formula：C₂₄H₂₄N₆O₂S₃	Package：Package according to customer requirements
Molecular Weight：524.681	Storage：Store at -20℃

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Remarks

BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.

References

[1]. Elgogary A, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36.

[2]. Meghan J. Seltzer, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010 Nov 15; 70(22): 8981-8987.