Product :
IU1
Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Chemical Information
Product name:IU1 |
Purity:98% min |
CAS NO:314245-33-5 |
Solubility:DMSO : ≥ 60 mg/mL (199.75 mM) |
Molecular Formula:C18H21FN2O |
Package:Package according to customer requirements |
Molecular Weight:300.371 |
Storage:Store at -20℃ |
Remarks
IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.