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IU1 314245-33-5
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Chemical Information
Product name:IU1 Purity:98% min
CAS NO:314245-33-5 Solubility:DMSO: >10mg/mL
Molecular Formula:C18H21FN2O Package:Packaging according to customer requirements
Molecular Weight:300.371 Storage:Store at +4°C
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IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.
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