BTSA1

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Chemical Information

Product name：BTSA1	Purity：98% min
CAS NO：314761-14-3	Solubility：DMSO : 25 mg/mL (58.07 mM)
Molecular Formula：C₂₁H₁₅N₅OS₃	Package：Package according to customer requirements.
Molecular Weight：449.572	Storage：-20 ℃

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Remarks

BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.

References

[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.