PTC-209

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Chemical Information

Product name：PTC-209	Purity：98% min
CAS NO：315704-66-6	Solubility：DMSO : ≥ 32 mg/mL (64.62 mM)
Molecular Formula：C₁₇H₁₃Br₂N₅OS	Package：Package according to customer requirements
Molecular Weight：495.191	Storage：Store at -20℃

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Remarks

PTC-209 is a potent BMI-1 inhibitor with potential anticancer activity. PTC-209 inhibits endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 decreases colorectal tumor cell growth in a BMI-1-dependent way. In addition, PTC-209 impairs colorectal cancer-initiating cells (CICs) through irreversible growth inhibition.

Properties:

density: 1.86±0.1 g/cm3(Predicted)

form: powder

pka: 3.77±0.30(Predicted)

color: white to brown

BMI-1 Inhibitors Related Products:

PTC-028

References

[1]. Kreso A, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014 Jan;20(1):29-36.

[2]. Christian Mayr, et al. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016 Jan 5; 7(1): 745-758.

[3]. Shahi MH, et al. BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance. PLoS One. 2015 Jun 25;10(6):e0131006.