BIBR 1532

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Chemical Information

Product name：BIBR 1532	Purity：98% min
CAS NO：321674-73-1	Solubility：DMSO : ≥ 100 mg/mL (301.79 mM)
Molecular Formula：C₂₁H₁₇NO₃	Package：Package according to customer requirements
Molecular Weight：331.365	Storage：Store at -20℃

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Remarks

BIBR1532 is a selective telomerase inhibitor. BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length.

References

[1]. Pascolo E, et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem. 2002 May 3;277(18):15566-72.

[2]. El-Daly H, et al. Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood. 2005 Feb 15;105(4):1742-9.

[3]. Ward RJ, et al. Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol. 2005 Sep;68(3):779-86.