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Calcitriol

Calcitriol 32222-06-3
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Chemical Information
Product name:Calcitriol Purity:98% min
CAS NO:32222-06-3 Solubility:DMSO : ≥ 100 mg/mL (240.02 mM)
Molecular Formula:C27H44O3 Package:Package according to customer requirements
Molecular Weight:416.636 Storage:Store at -20℃
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Remarks
Calcitriol exerts antiproliferative effects on cervical cancer cells in vitro. Cells decrease by 12.8% when treated with 100 nM Calcitriol for 6 days, compare with control. Inhibition of cell proliferation becomes more pronounced with the increase in Calcitriol concentration. The decrease is 26.1% and 31.6% for 200 and 500 nM Calcitriol, respectively. Treatment with Calcitriol for 72 h induces an evident accumulation of cells in the G1 phase, with approximately 66.18% in 200 nM and 78.10% in 500 nM, compare with the control (24.36%). Calcitriol treatment significantly decreases HCCR-1 protein expression compare with the control in a time- and dose-dependent manner. Calcitriol significantly increases ERα mRNA in a dose dependent manner with an EC50 of 9.8×10-9 M.
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