10-Deacetylbaccatin III

10-Deacetylbaccatin III, also known as 10-DAB or 10-DAB III, is a closely related natural organic compounds isolated from dried needles and small branches of the European yew tree (Taxus baccata).10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III was found to selectively inhibit the growth of L. DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM.

Properties:

Appearance & Physical State:  white solid

Density: 1.41 g/cm3

Boiling Point: 716.8ºC at 760 mmHg

Melting Point:  231-236ºC

Flash Point: 233.5ºC

Refractive Index: 1.624

Related Products:

Baccatine III; 7-Troc-paclitaxel; 7,10-Troc-10DAB; 7,10-Di Troc Docetaxel; 7,10-dimethoxy-10-DAB III

[1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26.

[2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.