Product :
Cinacalcet hydrochloride AMG-073 HCl
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Chemical Information
Product name:Cinacalcet hydrochloride AMG-073 HCl |
Purity:98% min |
CAS NO:364782-34-3 |
Solubility:DMSO : ≥ 50 mg/mL (126.95 mM) |
Molecular Formula:C22H23ClF3N |
Package:Package according to customer requirements |
Molecular Weight:393.873 |
Storage:Store at -20℃ |
Remarks
Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR. In the presence of calcium ions, it can inhibit parathyroid hormone secretion by activating CaSR in parathyroid glands. Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). Cinacalcet has been used clinically to treat secondary hyperparathyroidism due to end-stage renal disease or hypercalcemia in patients with parathyroid carcinoma.