AG-3-5 Icilin

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Chemical Information

Product name：AG-3-5 Icilin	Purity：98% min
CAS NO：36945-98-9	Solubility：DMSO : ≥ 54 mg/mL (173.47 mM)
Molecular Formula：C₁₆H₁₃N₃O₄	Package：Package according to customer requirements
Molecular Weight：311.292	Storage：Store at -20℃

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Remarks

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Although structurally not related with menthol it produces an extreme sensation of cold both in humans and animals. It is almost 200 times more potent than menthol and 2.5 times more efficacious. Despite their similar effects icilin activates the TRPM8 receptor in a different way. Icilin is effective in an experimental model of itch. It is now used as a research tool for the study of TRP channels.

References

[1]. Lee S, et al. Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10.

[2]. Andersson DA, et al. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 2004 Jun 9;24(23):5364-9.