anti-IL-6R Tocilizumab

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Chemical Information

Product name：anti-IL-6R Tocilizumab	Purity：98% min
CAS NO：375823-41-9	Solubility：Soluble in DMSO
Molecular Formula：C₁₄H₁₂O₃	Package：Package according to customer requirements.
Molecular Weight：	Storage：-20 ℃

Quality control

COA

Remarks

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis.

References

[1]. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70.

[2]. Mami Noda, et al. IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain. Int J Mol Sci. 2013 Jan; 14(1): 515–526.