Pyroxamide

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Chemical Information

Product name：Pyroxamide	Purity：98% min
CAS NO：382180-17-8	Solubility：Soluble in DMSO
Molecular Formula：C₁₃H₁₉N₃O₃	Package：Package according to customer requirements
Molecular Weight：265.308	Storage：Store at -20℃

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Remarks

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

References

1: Einsiedel HG, Kawan L, Eckert C, Witt O, Fichtner I, Henze G, Seeger K. Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia. Leukemia. 2006 Aug;20(8):1435-6. Epub 2006 Jun 29. PubMed PMID: 16810202.

2: Kouraklis G, Theocharis S. Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. 2006 Feb;15(2):489-94. Review. PubMed PMID: 16391874.