Product :
PAI-039 Tiplaxtinin
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Chemical Information
Product name:PAI-039 Tiplaxtinin |
Purity:98% min |
CAS NO:393105-53-8 |
Solubility:Soluble in DMSO |
Molecular Formula:C24H16F3NO4 |
Package:Package according to customer requirements |
Molecular Weight:439.383 |
Storage:Store at -20℃ |
Remarks
Tiplaxtinin, also known as PAI-039, is a novel plasminogen activator inhibitor-1 (PAI-1) inhibitor. The pharmacokinetic profile of PAI-039 indicated an oral bioavailability of 43 +/- 15.3% and a plasma half-life of 6.2 +/- 1.3 h. PAI-039 is an orally active prothrombolytic drug that inhibits PAI-1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI-039 exerts antithrombotic efficacy in rat models of arterial and venous vascular injury without effecting platelet aggregation. PAI-039 as a novel therapeutic may improve diabetic wound closure.