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JNJ 5207852 dihydrochloride

JNJ 5207852 dihydrochloride 398473-34-2
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Chemical Information
Product name：JNJ 5207852 dihydrochloride Purity：99% min
CAS NO：398473-34-2 Solubility：DMSO : 77.5 mg/mL (244.88 mM)
Molecular Formula：C20H32N2O Package：Package according to customer requirements
Molecular Weight：316.481 Storage：Store at -20℃
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Remarks
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
References

[1]. Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.

[2]. Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.

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