Product :
AG-670 ML-161
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Chemical Information
| Product name：AG-670 ML-161 |
Purity：98% min |
| CAS NO：423735-93-7 |
Solubility：DMSO : 100 mg/mL (276.83 mM) |
| Molecular Formula：C17H17BrN2O2 |
Package：Package according to customer requirements |
| Molecular Weight：361.233 |
Storage：Store at -20℃ |
Remarks
ML-161 is a potent and reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM. ML161 inhibited platelet aggregation induced by a PAR1 peptide agonist or by thrombin but not by several other platelet agonists. Initial studies suggest that ML161 is an allosteric inhibitor of PAR1. These findings may be important for the discovery of antithrombotics with an improved safety profile.
References
[1] Dockendorff C, et al. ACS Med Chem Lett, 2012, 3(3), 232-2