Eribulin Mesylate

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Chemical Information

Product name：Eribulin Mesylate	Purity：98% min
CAS NO：441045-17-6	Solubility：DMSO : ≥ 100 mg/mL (121.07 mM)
Molecular Formula：C₄₁H₆₃NO₁₄S	Package：Package according to customer requirements
Molecular Weight：826.002	Storage：Store at -20℃

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Remarks

Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. Eribulin mesylate (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

Related Products:

Eribulin mesylate intermediate; Eribulin intermediate ERA; Eribulin intermediate; Eribulin Intermediate(R); Eribulin Intermediate(S)

References

[1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11.

[2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7.

[3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505.