SB-681323 Dilmapimod

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Chemical Information

Product name：SB-681323 Dilmapimod	Purity：98% min
CAS NO：444606-18-2	Solubility：DMSO : 125 mg/mL (273.87 mM)
Molecular Formula：C₂₃H₁₉F₃N₄O₃	Package：Package according to customer requirements
Molecular Weight：456.417	Storage：Store at -20℃

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Remarks

Dilmapimod, also known as SB-681323 and GW-681323 , is p38 MAPK inhibitor. SB-681323 inhibited the p38 MAPK pathway to a greater degree than prednisolone did. SB-681323 inhibited TNF-alpha production. SB-681323 is a potent p38 MAPK inhibitor that potentially suppresses inflammation in COPD. The treatment with SB-681832 is a safe and effective means of reducing hsCRP in patients undergoing elective PCI.

References

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.