BAN ORL 24

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Chemical Information

Product name：BAN ORL 24	Purity：98% min
CAS NO：475150-69-7	Solubility：Soluble in DMSO
Molecular Formula：C₂₇H₃₅N₃O₂	Package：Package according to customer requirements
Molecular Weight：506.512	Storage：Store at -20℃

Quality control

COA

Remarks

BAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). IC50 value: 0.27 nM Target: NOP receptor BAN ORL 24 inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro. BAN ORL 24 antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

References

[1]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.