CP-690550 Tofacitinib

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Chemical Information

Product name：CP-690550 Tofacitinib	Purity：98% min
CAS NO：477600-75-2	Solubility：DMSO : ≥ 100 mg/mL (320.13 mM)
Molecular Formula：C₁₆H₂₀N₆O	Package：Package according to customer requirements.
Molecular Weight：312.370	Storage：Store at -20℃

Quality control

COA

Remarks

Tofacitinib, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

Related Prodcuts:

Tofacitinib citrate; Tofacitinib impurity; Tofacitinib Impurity R; Tofacitinib intB3; Tofacitinib intermediate(90213-66-4; 477600-71-8; 1062580-52-2; 3680-69-1)

References

[1]. Jiang JK, et al. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J Med Chem. 2008 Dec 25;51(24):8012-8.

[2]. Onda M, et al. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1;193(1):48-55.