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Product :

Genz-123346

Genz-123346 491833-30-8
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Chemical Information
Product name:Genz-123346 Purity:98% min
CAS NO:491833-30-8 Solubility:DMSO : ≥ 100 mg/mL (238.91 mM)
Molecular Formula:C24H38N2O4 Package:Package according to customer requirements
Molecular Weight:418.570 Storage:Store at -20℃
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Remarks
Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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