Welcome to Crene Biotechnology!

+86-576-88205808

Product :

TPPB

TPPB 497259-23-1
Size Price Stock Quantity
Get Quotation Now Add to Cart Bulk Inquiry
Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Chemical Information
Product name:TPPB Purity:98% min
CAS NO:497259-23-1 Solubility:DMSO : 135 mg/mL (269.17 mM)
Molecular Formula:C27H30F3N3O3 Package:Package according to customer requirements
Molecular Weight:501.541 Storage:-20 ℃
Quality control
COA
Remarks

TPPB is used in Biotrickling filter modeling for styrene abatement.

 

In Vitro:

By use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e). TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells. TPPB at concentration of 1 μM could antagonize Aβ25-35 induced cell damage. TPPB could increase the phosphorylation of Akt, PKC, MARCKS and MAPK, which are inhibited by Aβ25-35 treatment. TPPB inhibits the activation of caspase-3 induced by Aβ25-35.

 

In Vivo:

TPPB is evaluated for induction of hyperplasia after topical application to the shaved backs of outbred Sencar mice and shows a modest response at 300 μg.

References
[1]. Kozikowski AP, et al. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem. 2003 Jan 30;46(3):364-73.
[2]. Yang HQ, et al. Neuroprotective effects of new protein kinase C activator TPPB against Aβ~ ~~ induced neurotoxicity in PC12 cells. Neurochem Res. 2012 Oct;37(10):2213-21.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Friendly link:

Copyright Copyright (C) 2018-2024 Taizhou Crene Biotechnology Co.,Ltd.  

Address:Economic Developed Zone of Taizhou Zhejiang China