Hydrocortisone (Cortisol)

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Chemical Information

Product name：Hydrocortisone (Cortisol)	Purity：98% min
CAS NO：50-23-7	Solubility：DMSO : ≥ 31 mg/mL (85.53 mM)
Molecular Formula：C₂₁H₃₀O₅	Package：Package according to customer requirements
Molecular Weight：362.46	Storage：Store at -20℃

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Remarks

Hydrocortisone is an endogenous hormone and glucorticoid receptor agonist involved in stress signaling. It is used to treat dermatologic diseases and severe allergic reactions. It stimulates gluconeogenesis, inhibits inflammatory cytokine production, and shifts the immune response from Th1 to Th2 subtype.

Properties:
Appearance & Physical State crystalline white powder
Density 1.28g/cm3
Boiling Point 566.4ºC at 760 mmHg
Melting Point 213-220ºC
Flash Point 310.4ºC
Refractive Index 1.594

Glucocorticoid Receptor Agonists Related Products:

Betamethasone; Dexamethasone; Mifepristone; Desonide; Clobetasol propionate; Desoximetasone

References

[1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.

[2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.